Lilya Matyunina


Research Scientist II

Research Interests:

  • Ovarian cancer
  • Transposable elements (host-element interaction)

315 Ferst Drive NW
Atlanta, GA-30332, U.S.A.
Office: IBB 3217
Email: lilya(dot)matyunina(at)biology(dot)gatech(dot)edu
Phone: 404.385.6629
Fax: 404.894.2219
Professional Experience
Research Scientist II School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA 2004 – Present
Post Doctoral Associate Department of Genetics, University of Georgia, Athens, GA, USA 1993 – 2004
Senior Scientist Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia 1991 – 1993
Research Assistant Siberian Institute of Horticultuer, Barnaul, Russia 1988 – 1991
Research Assistant Altay Institue of Cattle Breeding, Barnaul, Russia 1985 – 1988


PhD, Molecular Genetics N.I Vavilov Institute of General Genetics, RAS, Moscow, Russia 1987
MS, Biochemistry Altay State University, Barnaul, Russia 1981

Selected Publications

Hill CG, Jabbari N, Matyunina LV, McDonald JF. 2014 Functional and evolutionary significance of human microRNA seed region mutations. PLoS One. 2014 Dec 12;9(12):e115241. doi: 10.1371/journal.pone.0115241. eCollection 2014.

Hill CG, Matyunina LV, Walker D, Benigno BB, McDonald JF. 2014 Transcriptional override: a regulatory network model of indirect responses to modulations in microRNA expression BMC Syst Biol. 2014 Mar 25;8:36. doi: 10.1186/1752-0509-8-36.

Lili LN, Matyunina LV, Walker LD, Daneker GW, McDonald JF. 2014 Evidence for the importance of personalized molecular profiling in pancreatic cancer. Pancreas. 2014 Mar;43(2):198-211. doi: 10.1097/MPA.0000000000000020.

Ghosh D, Lili L, McGrail DJ, Matyunina LV, McDonald JF, Dawson MR. 2014 Integral role of platelet-derived growth factor in mediating transforming growth factor-β1-dependent mesenchymal stem cell stiffening. Stem Cells Dev. 2014 Feb 1;23(3):245-61.

Lili LN, Matyunina LV, Walker LD, Wells SL, Benigno BB, McDonald JF. 2013 Molecular profiling supports the role of epithelial-to-mesenchymal transition (EMT) in ovarian cancer metastasis. J Ovarian Res. 2013 Jul 10;6(1):49. doi: 10.1186/1757-2215-6-49.

Lili LN, Matyunina LV, Walker LD, Benigno BB, McDonald JF. 2013 Molecular profiling predicts the existence of two functionally distinct classes of ovarian cancer stroma. Biomed Res Int. 2013;2013:846387. doi: 10.1155/2013/846387. Epub 2013 May 9.

Shahab SW, Matyunina LV, Hill CG, Wang L, Mezencev R, Walker LD, McDonald JF. 2012 The effects of MicroRNA transfections on global patterns of gene expression in ovarian cancer cells are functionally coordinated. BMC Med Genomics. 2012 Aug 1;5:33. doi: 10.1186/1755-8794-5-33.

Liu Y, Bowen NJ, Matyunina L, McDonald J, Prausnitz MR. 2012 Gene transfection enhanced by ultrasound exposure combined with drug treatment guided by gene chip analysis. Int J Hyperthermia. 2012;28(4):349-61. doi: 10.3109/02656736.2012.669513.

Wang L, Mezencev R, Bowen NJ, Matyunina LV, McDonald JF. 2012 Isolation and characterization of stem-like cells from a human ovarian cancer cell line. Mol Cell Biochem. 2012 Apr;363(1-2):257-68. doi: 10.1007/s11010-011-1178-6. Epub 2011 Dec 9.

Shahab SW, Matyunina LV, Mezencev R, Walker LD, Bowen NJ, Benigno BB, McDonald JF. 2011 Evidence for the complexity of microRNA-mediated regulation in ovarian cancer: a systems approach. PLoS One. 2011;6(7):e22508. doi: 10.1371/journal.pone.0022508. Epub 2011 Jul 21.

Chen J, Wang L, Matyunina LV, Hill CG, McDonald JF. 2011 Overexpression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastatic ovarian cancer cells. Gynecol Oncol. 2011 Apr;121(1):200-5. doi: 10.1016/j.ygyno.2010.12.339. Epub 2011 Jan 28.

Liu Y, Chen Y, Momin A, Shaner R, Wang E, Bowen NJ, Matyunina LV, Walker LD, McDonald JF, Sullards MC, Merrill AH Jr. 2010 Elevation of sulfatides in ovarian cancer: an integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry. Mol Cancer. 2010 Jul 12;9:186. doi: 10.1186/1476-4598-9-186.

Bowen NJ, Walker LD, Matyunina LV, Logani S, Totten KA, Benigno BB, McDonald JF. 2009 Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells. BMC Med Genomics. 2009 Dec 29;2:71. doi: 10.1186/1755-8794-2-71.

Matyunina LV, Bowen NJ, McDonald JF. 2008 LTR retrotransposons and the evolution of dosage compensation in Drosophila. BMC Mol Biol. 2008 Jun 4;9:55. doi: 10.1186/1471-2199-9-55.

Menendez L, Walker LD, Matyunina LV, Totten KA, Benigno BB, McDonald JF. 2008 Epigenetic changes within the promoter region of the HLA-G gene in ovarian tumors. Mol Cancer. 2008 May 22;7:43. doi: 10.1186/1476-4598-7-43.

Moreno CS, Matyunina L, Dickerson EB, Schubert N, Bowen NJ, Logani S, Benigno BB, McDonald JF.2007. Evidence that p53-Mediated Cell-Cycle-Arrest Inhibits Chemotherapeutic Treatment of Ovarian Carcinomas.PLoS ONEMay 16;2:e441

Menendez L, Walker D,Matyunina L.V., Dickerson E.B., Bowen N.J., Polavarapu N., Benigno B.B, McDonald J.F.2007. Identification of candidate methylation-responsive genes in ovarian cancer.Mol Cancer. Jan 25;6:10.

Jordan I.K.,Matyunina L.V., McDonald J.F. 1999. Evidence for the recent horizontal transfer of long terminal repeat retrotransposon. Proc Natl Acad Sci USA. Oct26;96(22):12621-5

Wilson S, Matyunina L.V., McDonald J.F. 1998. An enhancer region within the copia untranslated leader contains binding sites for Drosophila regulatory proteins. Gene Mar 16;209(1-2):239-46

McDonald JF, Matyunina L.V., Wilson S, Jordan I.K., Bowen N.J., Miller W.J. 1997. LTR retrotransposons and the evolution of eukaryotic enhancers. Genetica 100(1-3):3-13.

Matyunina L.V., Jordan I.K., McDonald J.F. 1996. Naturally occurring variation in copia expression is due to both element(cis) and host(trans) regulatory variation. Proc Natl Acad Sci USA Jul 9;93(14):7097-102.

Gerasimova T.I., Matyunina L.V., Ilyin Y.V. and Georgiev G.P. 1985. Simultaneous transpositions of different mobile elements: relation to multiple mutagenesis in Drosophila melanogaster. MGG 194: 517-22.